Creamy Turkey Tetrazzini Casserole: A Comforting Family Favorite

When the weather turns chilly or you’re simply craving something comforting, few dishes can match the satisfaction of a warm, creamy casserole. Creamy Turkey Tetrazzini Casserole is the perfect combination of tender turkey, velvety sauce, and gooey melted cheese, all baked together in one irresistible dish. Whether you’re looking to use up leftover turkey from Thanksgiving or want a hearty, flavorful meal for a weeknight dinner, this dish is guaranteed to be a hit with your family.

Let’s take a deep dive into this classic recipe, including why it’s a must-make, step-by-step instructions, and tips to perfect it every time.

Why You’ll Love Creamy Turkey Tetrazzini Casserole

There’s so much to love about this dish, from its taste to its convenience:

• Perfect for Leftovers: If you have leftover turkey, this is a fantastic way to repurpose it into a new and exciting meal.
• Rich and Creamy Flavor: The garlic-flavored cream cheese, half-and-half, and mozzarella combine for a luxurious, velvety sauce.
• Hearty and Filling: With protein-packed turkey, mushrooms, and spaghetti, this casserole is a complete, satisfying meal.
• Crowd-Pleasing: Its cheesy top layer and comforting flavor make it perfect for family gatherings or potlucks.
• Make-Ahead Friendly: You can assemble this casserole ahead of time and bake it when you’re ready, making it an easy option for busy days.

Ingredients for Creamy Turkey Tetrazzini Casserole

Here’s everything you’ll need to create this delicious casserole:

Ingredient	Quantity	Purpose
Cooked diced turkey	2 cups	Provides tender protein and hearty texture.
Onion (diced)	1 medium	Adds sweetness and depth to the dish.
Dried spaghetti	12 ounces	The base that holds the creamy casserole together.
Sliced mushrooms	¾ pound	Adds an earthy flavor and texture.
Unsalted butter	3 tablespoons	Used for sautéing and creating the roux.
Garlic (minced)	3 cloves	Provides aromatic depth to the dish.
All-purpose flour	3 tablespoons	Thickens the creamy sauce.
Chicken broth	2 cups	Forms the liquid base of the sauce.
Garlic-flavored cream cheese	8 ounces	Adds creamy richness with a subtle garlic flavor.
Half-and-half (or light cream)	1 ⅓ cups	Creates the smooth, velvety sauce.
Fresh parsley (chopped)	1 tablespoon	Adds brightness and a fresh garnish.
Shredded mozzarella cheese	2 cups	Creates a gooey, cheesy topping.
Grated Parmesan cheese	¼ cup	Adds a nutty, salty flavor to the top.
Italian seasoning	1 teaspoon	Enhances the casserole with classic herb flavors.
Salt	To taste	Balances and enhances the flavors.
Ground black pepper	To taste	Adds mild heat and complexity.

Step-by-Step Recipe for Creamy Turkey Tetrazzini Casserole

1. Preheat Your Oven

• Preheat your oven to 350°F (175°C).
• Grease a 9×13-inch baking dish with butter or cooking spray to prevent sticking.

2. Cook the Spaghetti

• Bring a large pot of salted water to a boil.
• Add the dried spaghetti and cook according to package instructions until al dente.
• Drain the pasta and set it aside.

3. Sauté the Vegetables

• In a large skillet, melt 2 tablespoons of unsalted butter over medium heat.
• Add the diced onion and sliced mushrooms. Sauté for 5-7 minutes, stirring occasionally, until the onions become translucent and the mushrooms are tender.
• Stir in the minced garlic and cook for another 1-2 minutes until fragrant.
• Remove the skillet from heat and set the vegetables aside.

4. Make the Creamy Sauce

• Using the same skillet, melt the remaining 1 tablespoon of butter over medium heat.
• Sprinkle the all-purpose flour into the skillet, stirring constantly for about a minute to create a roux.
• Slowly pour in the chicken broth while whisking to prevent lumps, creating a smooth base.
• Add the garlic-flavored cream cheese, stirring until it melts completely and incorporates into the sauce.
• Gradually add the half-and-half (or light cream), continuing to stir until the sauce is creamy and thickened, about 5 minutes.
• Mix in the chopped parsley, Italian seasoning, salt, and black pepper. Remove from heat.

5. Combine the Ingredients

• In a large mixing bowl, combine the cooked spaghetti, diced turkey, sautéed vegetables, and creamy sauce.
• Stir until all ingredients are evenly coated and distributed.

6. Assemble the Casserole

• Transfer the pasta mixture into the prepared 9×13-inch baking dish.
• Spread the mixture evenly in the dish.
• Sprinkle the shredded mozzarella cheese and grated Parmesan cheese evenly across the top.

7. Bake

• Cover the baking dish with foil to prevent the cheese from overbrowning.
• Bake the casserole in the preheated oven for 30 minutes.
• Remove the foil and continue baking for an additional 10-15 minutes, or until the cheese is golden and bubbling.

8. Serve and Enjoy

• Remove the casserole from the oven and let it rest for a few minutes before serving.
• Garnish with additional chopped parsley for a fresh, vibrant touch.
• Serve hot and enjoy this creamy, cheesy comfort dish!

What Makes This Recipe Special?

1. Perfect Use of Leftovers

This dish is ideal for using up leftover turkey from Thanksgiving or other occasions, transforming it into a brand-new meal that feels special.

2. Rich, Creamy Sauce

The combination of garlic-flavored cream cheese, half-and-half, and chicken broth creates a sauce that’s indulgent without being too heavy.

3. Melted Cheese Topping

The golden, bubbly layer of mozzarella and Parmesan cheese adds a deliciously gooey, slightly crisp finish that makes every bite irresistible.

Nutritional Highlights

Nutrient	Source	Benefit
Protein	Turkey, cheese	Builds and repairs muscle tissue.
Calcium	Mozzarella, Parmesan	Supports bone health and strength.
Vitamins	Onions, mushrooms	Boosts immunity and overall health.
Healthy Fats	Butter, cream cheese	Provides energy and enhances flavor.
Carbohydrates	Spaghetti	Provides sustained energy and fullness.

Tips for Perfecting Creamy Turkey Tetrazzini Casserole

1. Use Fresh Turkey: While leftovers work great, freshly cooked turkey will give the best texture and flavor.
2. Don’t Overcook the Pasta: Keep the spaghetti al dente to prevent it from becoming mushy when baked.
3. Customize Vegetables: Add spinach, peas, or bell peppers for extra color and nutrients.
4. Add a Crispy Topping: For a crunchy twist, sprinkle breadcrumbs or crushed crackers over the cheese before baking.
5. Make It Ahead: Assemble the casserole up to 24 hours in advance and bake it when ready to serve.

FAQs About Creamy Turkey Tetrazzini Casserole

1. Can I use chicken instead of turkey?

Absolutely! Cooked, shredded chicken works just as well in this recipe.

2. Can I make this casserole ahead of time?

Yes! You can assemble the casserole up to a day in advance and refrigerate it. Bake it fresh when you’re ready.

3. Can I freeze this casserole?

Yes. Assemble the casserole, but don’t bake it. Cover it tightly with plastic wrap and foil, then freeze for up to 3 months. Bake from frozen, adding 10-15 minutes to the cooking time.

4. Can I use a different type of pasta?

Definitely! Penne, fettuccine, or rotini are great alternatives to spaghetti.

5. How do I store leftovers?

Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven or microwave.

6. Can I make this dish gluten-free?

Yes! Use gluten-free pasta and substitute the all-purpose flour with a gluten-free alternative, such as rice flour.

Why You Should Try Creamy Turkey Tetrazzini Casserole Tonight

Creamy Turkey Tetrazzini Casserole is more than just a meal—it’s a warm, comforting hug in a dish. From its cheesy topping to its savory sauce, every bite is bursting with flavor. This dish is easy to prepare, versatile, and loved by both kids and adults, making it the ultimate comfort food for any occasion.

Make It Tonight!

Gather your ingredients and make this Creamy Turkey Tetrazzini Casserole tonight. Whether you’re feeding a crowd or just want leftovers for the week, this recipe is guaranteed to impress. One bite, and it’ll become a family favorite for years to come!

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